The most substantial problem in the treatment of obesity is sustaining the weight loss of the individual. Because the body and the person’s mind becomes familiar with maintaining a specific weight, the body is actually working towards maintaining the individual at an obese level. Some individuals have it even worse with genetic, epigenetic, and neuro-hormonal action that make it even more difficult to lose the weight and keep it off. As a result some physicians are turning to an approach of weight loss that centers on both physiological and behavioral psychological therapies. Physicians that specialize in weight loss have also been looking at creating more individualized weight loss programs. They are looking to overcome the gap of both basic and the clinical sciences to better target on individuals specific weight gaining issues. People tend to respond to weight control therapies differently. Some individuals lose large amounts of weight, some only lose a small portion of weight, and even others gain weight with some of the therapies. As a result it has become overwhelmingly clear that weight loss therapies need to be specialized for the individual, monitored, and the techniques that show the most positive results need to be maintained. There needs to be more than just an understanding of biology when it comes to weight loss. The behavioral sciences is an integral part of the weight loss process. Recognizing and understanding the strengths of a specific patient is key in finding and building a successful weight loss program. Currently a group called NIH is attempting to fully identify all the barriers that prevent patient’s from actualizing weight loss. Reviewing a patient’s results and making changes to the weight management plan accordingly is imperative for success. The current popular diets on the market have shown to fail time and time again for the vast majority of individuals. It is a common misconception that the obese do not care about their weight or their appearance. The general population needs to recognize that the obese are extremely aware of their weight and can even be hypersensitive to changes in their appearance. This however is not a reflection of their eating habits. There are often psychological and biological factors that prevent the gap between their hypersensitivity to their weight and their dietary behaviors from connecting. As a result attempts to lose weight are often short lived, inefficient, or lack the motivation to complete. Currently there is no magic pill that helps dramatically with weight loss without side effects. The best results come when people have their behavior analyzed along with their body chemistry so they can reshape the way they think. Without that the obese are likely to fall back into previous habits and dietary habits.